How Long Does It Take for CBD to Work?

July 30, 2021By Matt McNeill

Table of Content

The effects usually last between 30 minutes and 2 hours and can last 4 to 6 hours. Finding what works best for you requires starting with a lesser dose and selecting high-quality items.

If you’re new to CBD, you might have questions about what to expect. Aside from the possible benefits, we often ask, “How long does it take for CBD to work?”

We’ve gathered all you need to know about how CBD interacts with the body so that you can reasonably expect how long its effects will take to occur.

How does CBD interact with the body?

CBD interacts with a body differently from most cannabinoids, affecting different receptor types. Typically, cannabinoids exert their effects on the body by binding to cannabinoid receptors like CB1 and CB2. CBD, however, can only weakly bind to CB1 and CB2, meaning that cannabinoid receptors are not an effective means of action. Instead, CBD’s effects occur by the cannabinoid binding to non-cannabinoid receptors and acting on other receptor pathways.

The receptor that CBD binds to will determine the effects that you experience. If a CBD binds to a serotonin receptor, you might feel reduced anxiety, whereas if it binds to a glycine receptor, you might experience reduced inflammation (6, 7).

What is CBD?

CBD comes in many forms.

The science bit: CBD is a chemical compound found in and extracted from cannabis and hemp plants. Also known as CBD, this chemical belongs to a family of compounds called cannabinoids. Native to cannabis and hemp plant groups, cannabinoids can interact with our bodies when consumed to induce a range of potential effects.

What about the benefits?

CBD is best known for its potential health benefits. Research shows that CBD holds significant health potential, with evidence that it may improve the symptoms of anxiety, pain, sleep, and inflammation (1, 2, 3, 4).

CBD is available in a range of products, including the popular CBD balm and sleep patches, which help people relax and recover.

How you take CBD matters

How you consume CBD will alter how quickly you feel its effects. Different consumption methods affect different biological systems, with varying forces impacting how quickly CBD reaches your bloodstream to induce its effects.

As well as affecting the speed of delivery, different consumption methods will also determine CBD strength. This is known as the bioavailability of a consumption method. The higher the bioavailability percentage, the higher the amount of CBD that reaches the bloodstream. A high bioavailability percentage means you will experience stronger effects from the CBD.

Ingestion

Ingesting CBD will likely leave you with a longer wait time to experience the full effects. Because of the slow absorptive nature of the gut, you should expect edible products to peak roughly 1.5 to 4 hours after ingestion (8).

CBD edibles might last a while but are not the hardest-hitting product available. Because CBD degrades in the strongly metabolic gut, you can expect a relatively low amount of CBD to reach your bloodstream when you eat it, with a bioavailability hovering around 6-20% (9).

Inhalation

Inhaling CBD smoke or vapour will transport the cannabinoid’s effects to you quickly. This speedy delivery is because inhalation passes smoke and vapour through the lungs, which contain extremely permeable tissue that allow CBD to get to your bloodstream faster. With CBD inhalation you can expect to feel peak results as early as three minutes after consumption (10).

The effects of inhaling CBD are also likely to be strong. Smoking CBD can result in a bioavailability of roughly 31%, while vaping can reach a whopping 70% (11, 12).

Sublingual

Applying CBD under the tongue can be a way to take CBD with slightly quicker and stronger effects than edibles. Placing CBD oil under the tongue rather than swallowing it might not seem like much of a difference, but the structure of the tongue may provide a quicker delivery. The underside of the tongue contains a mucous membrane that can absorb CBD and transfer it to the blood more effectively than if it had to go through the gut. You can expect to feel CBD’s peak effects at around 2 hours after consumption (13).

Transdermal

Transdermal products like CBD patches are designed to reach your bloodstream by travelling through your skin. The time it takes for you to feel the effects of CBD will depend on the specific makeup of the product. These typically add additional ingredients to help CBD penetrate your skin. Transdermal patches can take a few hours to a day to induce their peak effects on the body.

Due to its nature, CBD cannot reach the bloodstream through the skin alone. CBD is lipophilic, meaning that it can’t dissolve in oil. Our skin has an oil layer, and to cross it, CBD must be “carried” across through additional ingredients like those found in transdermal CBD products.

The key benefits of transdermal CBD are that it allows for easy delivery while avoiding the gut, which degrades CBD and leaves you with a lower bioavailability. An effective transdermal CBD product should leave you with stronger effects than an edible CBD product (14).

Topical

While they are placed on the skin like transdermal CBD products, topical CBD differs in that it is not designed to reach the bloodstream. Topical CBD products like lotions and shampoos are meant to induce a local effect on the area of the skin that they are applied to. Because of this, you may feel local effects from topical CBD relatively quickly.

How dosage affects duration

Because of how different consumption methods metabolise CBD, the time it takes for CBD’s effects to be felt in the body will be roughly the same regardless of the dose. The biggest difference you will experience from a higher dose is the strength of those effects. Some slight time may be added to the duration due to the additional metabolism required.

The bottom line

When it comes to CBD, the method you use to consume it will significantly affect how long it will take to work. Some methods will leave you waiting a few hours before you experience the peak effects of the cannabinoid, while others can deliver you results in minutes.

You may also be interested to read about The Difference between Hemp Oil and CBD Oil.

Medically reviewed for KLORIS by Sarah Neidler, PhD

Matt McNeill

Matt is one of the co-founders of KLORIS, where he’s passionate about creating natural wellness products that genuinely put customers first. With a deep commitment to quality and sustainability, I work closely with scientists and wellbeing experts to craft products that are not only effective but also a joy to use.